Hydrophilic vs lipophilic statins

Author: eryy

August undefined, 2024

Web1 mei 2024 · This population‐based study included 114,929 patients undergoing chronic dialysis, retrieved from the Registry for Catastrophic Illness Patients from the National Health Insurance Research Database in Taiwan from 2000 to 2013, and found hydrophilic statins were significantly associated with lower risk of cardiovascular disease compared … WebThe main differences between hydrophilic statins and lipophilic statins are highlighted here. Hydrophilic statins are water-soluble, thus requiring active transport to be …

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Web9 mrt. 2024 · Background Statins are effective lipid-lowering drugs for the prevention of cardiovascular disease, but muscular adverse events can limit their use. Hydrophilic … Web13 nov. 2024 · It has been hypothesized that the lipophilic statin drugs are more likely to reach and readily enter extrahepatic cells, whereas hydrophilic statins are more hepatoselective ( 56 ). gp mobile corporate office

[PDF] Hydrophilic vs lipophilic statins in coronary artery disease: …

Web28 jun. 2024 · Hydrophilic Vs Lipophilic Statins. Since the introduction of lovastatin in 1987 as the first 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitor approved for human therapy, statins have become the most widely used lipid-lowering drugs with proven effect in cardiovascular disease prevention in different clinical settings . Web22 jan. 2024 · Lipophilic statins are widely distributed in different tissues, whereas hydrophilic statins are liver specific . Lipophilic statins include atorvastatin, simvastatin, … Web1 mei 2024 · The predominantly lipophilic statins (simvastatin, fluvastatin, pitavastatin, lovastatin and atorvastatin) can easily enter cells, whereas hydrophilic statins … gp mobile tracker

Statin Use Has No Negative Impact on Neurocognitive Health, …

Lipophilic vs. hydrophilic statins and psychiatric …

WebHydrophilic statins were significantly associated with lower RRs of psychiatric hospitalization but not of ED visits, compared to lipophilic statins. Conclusion The reduction in psychiatric hospitalizations in statin users (vs. nonusers) should be interpreted cautiously, as it carries a high risk of confounding by indication. child\u0027s neck pillowWeb1 mei 2024 · The results from different studies are conflicting regarding the benefit and safety of different classes of statins (lipophilic or hydrophilic) in the prevention of CAD as well as in the outcomes of patients with established CAD. 18, 21, 38, 39 This meta-analysis compared the safety and clinical efficacy of the 2 types of statins, lipophilic and … gp modifier for medicaid

"Web6 sep. 2024 · There was no difference concerning ox-LDL concentration between treatments with hydrophilic and lipophilic statins (SMD: -0.129, 95% CI: -0.330, -0.071, ; : 45.3%), but there was a significant reduction in circulating concentrations of ox-LDL associated with statin plus ezetimibe combination therapy when compared with statin … " - Hydrophilic vs lipophilic statins

Hydrophilic vs lipophilic statins

Abstract 17590: Hydrophilic Statins Are Associated With a ... - Circulation

Web5 mei 2024 · Demyanets et al reported that lipophilic but not hydrophilic statins induce a pro-apoptotic state in human adult cardiac myocytes in vitro.19 They showed that … Web22 jun. 2024 · Investigators also highlighted no significant differences were observed for any of the outcomes of interest based on use of hydrophilic or lipophilic statins. Further analysis suggested baseline neurocognitive function was an effect modifier for the associations of statins with dementia ( P for interaction <.001) and memory change ( P …

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Web9 jun. 2024 · Hydrophilic statins are liver specific, whereas lipophilic statins are widely distributed in different tissues. Objective: to examine whether hydrophilic or lipophilic statins are associated with a lower risk of incident heart failure (HF). Web1 mrt. 2005 · In addition,statins increase HDL cholesterol andlower triglycerides in the blood.Besides the lipid-lowering capabilities,this therapeutic group of drugs …

Web13 mrt. 2024 · Some available experimental studies have reported that hydrophilic statins might have advantages compared with lipophilic statins in patients with coronary artery disease (CAD). Therefore, we … Web3 jun. 2024 · Compared with patients receiving lipophilic statins, those receiving hydrophilic statins showed a lower prevalence of diabetes and higher hemoglobin and eGFR …

Web28 aug. 2007 · Lipophilic statins cross the blood-brain barrier more readily, which may lead to central nervous system complaints such as insomnia, although this is rare.Hydrophilic statins exhibit greater ... Web28 mrt. 2024 · The incidence rate of OCSCC was significantly lower in statin users compared to nonusers (17.12 vs. 26.75 per 10 000 person-years), yielding an incidence rate ratio of 0.64. ... The risk of OCSCC was lower among users of both hydrophilic and lipophilic statins. Conclusion.

Web23 apr. 2013 · It appears lipophilic statins produce better survival and other outcome benefits compared to hydrophilic statins. But the two types have not been compared in direct comparison trials in HF. Methods/design. We will conduct a systematic review and meta-analysis of lipophilic and hydrophilic statin therapy in patients with HF. Our …

Web20 mei 2024 · Hydrophilic vs. Lipophilic Statins. Since the introduction of lovastatin in 1987 as the first 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitor approved for human therapy, statins have become the most widely used lipid-lowering drugs with proven effect in cardiovascular disease prevention in different clinical settings … child\u0027s neck pillow for travelWeb1 jun. 2024 · The independent between-group ANOVA yielded a statistically significant effect, F (2, 59) = 6.69, p < 0.05, ⴄ2 = 0.21 in the spine. Thus, patients on lipophilic statins had statistically lower BMD than females on hydrophilic statins. The visual depiction of the means and 95% confidence intervals is presented in Fig. 3. gp modifier reductionWeb5 mei 2024 · Background: Studies comparing the cardiac consequences of hydrophilic and lipophilic statins in experimental and clinical practice settings have produced inconsistent results. In particular, evidence focusing on diabetic patients after acute myocardial infarction (AMI) is lacking. Methods and Results: Conclusions: In the present diabetic patients with … gpm of 2 inch pipeWebOverlap propensity score-weighted logistic regression analyses were assessed to determine associations of the prior use of statins (any statin, hydrophilic statins vs. lipophilic statins) with incident gastric cancer and its mortality depending on the medication duration (<180 days, 180–545 days, and >545 days) after adjusting for multiple covariates. child\u0027s need for agencyWeb22 jun. 2024 · No differences were found in any of the primary outcomes between users of hydrophilic versus lipophilic statins. These results are encouraging, but a randomized … child\u0027s neck pillow patternWebLipophilic statins were superior to hydrophilic rosuvastatin regarding all-cause mortality (OR 0 · 50; 95 % CI, 0 · 11-0 · 89; p = 0 · 01), cardiovascular mortality (OR 0 · 61; 0 · 25 … child\\u0027s need for agencyWebHydrophilic statins (pravastatin, rosuvastatin) may cause less muscular events than lipophilic statins (e.g. simvastatin, atorvastatin) due to lower passive diffusion into … child\\u0027s neck pillow