Phosphopantetheine adenylyltransferase
WebFeb 1, 2024 · Phosphopantetheine Adenylyltransferase (PPAT) is an enzyme that catalyzes the penultimate step in the biosynthesis of Coenzyme A (CoA), which is the active and physiologically functional form of ... WebProtein target information for Phosphopantetheine adenylyltransferase (Vibrio vulnificus YJ016). Find diseases associated with this biological target and compounds tested …
Phosphopantetheine adenylyltransferase
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WebFeb 1, 2024 · Phosphopantetheine adenylyltransferase (PPAT) is an essential enzyme in bacteria that catalyzes the rate-limiting step in coenzyme A (CoA) biosynthesis by … WebPhosphopantetheine Adenylyltransferase (PPAT) is an enzyme that catalyzes the penultimate step in the biosynthesis of Coenzyme A (CoA), which is the active and …
WebFeb 19, 2024 · The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A … WebThe coenzyme A (CoA) biosynthesis pathway has attracted attention as a potential target for much-needed novel antimicrobial drugs, including for the treatment of tuberculosis (TB), the lethal disease caused by Mycobacterium tuberculosis (Mtb). Seeking to identify inhibitors of Mtb phosphopantetheine …
WebMay 30, 2024 · In this study, phosphopantetheine adenylyltransferase (PPAT/CoaD) enzyme, involved in the coenzyme A biosynthesis pathway, was evaluated in the context of fragment-based discovery of new inhibitors targeting Mycobacterium abscessus. The structures of PPAT from M. abscessusMab PPAT, facilitating the initiation of a structure … Webpantetheine-phosphate adenylyltransferase Synonyms 3′-dephospho-CoA pyrophosphorylase PPAT dephospho-CoA pyrophosphorylase dephospho-coenzyme A pyrophosphorylase pantetheine phosphate adenylyltransferase Additional information <3, 4> (<3,4> with EC 2.7.1.24 part of a bifunctional enzyme with EC 2.7.1.24 [4,5]) [4, 5] CAS …
WebPhosphopantetheine adenylyltransferase (PPAT) cat-alyzes the penultimate step in coenzyme A (CoA) biosyn-thesis: the reversible adenylation of 4*-phosphopante-theine yielding 3*-dephospho-CoA and pyrophosphate. Wild-type PPAT from Escherichia coli was purified to homogeneity. N-terminal sequence analysis revealed
WebOct 3, 2001 · Phosphopantetheine adenylyltransferase (PPAT) is an essential enzyme in the coenzyme A pathway that catalyzes the reversible transfer of an adenylyl group from ATP … pink city swimming pool jaipurWebSep 18, 2024 · Crystal structure of the complex of phosphopantetheine adenylyltransferase from Acinetobacter baumannii with Phosphonoacetate at 2.19 A resolution. DOI: 10.2210/pdb6KYG/pdb Deposited: 2024-09-18 Released: 2024-10-09 haapaniemi heidiWebPhosphopantetheine adenylyltransferase (PPAT) regulates the key penultimate step in the essential coenzyme A (CoA) biosynthetic pathway. PPAT catalyzes the reversible transfer … pink city market jaipurWebMar 2, 2024 · Phosphopantetheine Adenylyltransferase: A promising drug target to combat antibiotic resistance. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics … pink city hotel in jaipurWeb7.11.3.6 Phosphopantetheine Adenylyltransferase (coaD Gene Product) The penultimate CoA biosynthetic enzyme catalyzes the reversible Mg 2+-dependent adenylylation of 4′ … pink ckx helmetWebOct 3, 2003 · In coenzyme A, 4′-phosphopantetheine is covalently linked to an adenylyl group, whereas it is covalently linked to a serine hydroxyl group in acyl carrier proteins. 4′-phosphopantetheine is cofactor of enzymes that play a role in the biosynthesis of fatty acids, polypeptide antibiotics, and polyketides ( 2 ). pink cm ovulationWebJan 25, 2002 · Phosphopantetheine adenylyltransferase (PPAT) catalyzes a key regulatory step in the coenzyme A (CoA) biosynthetic pathway: 1 the reversible transfer of an … haapaniemi iisalmi