Tim4 gene name

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August undefined, 2024

WebTargeted disruption of the Tim4 gene The Tim4-targeted mice were generated as custom order by Unitech (Kashiwa, Chiba, Japan). In brief, the Tim4 chromosomal gene was isolated from BAC clones of C57BL/6 mice, and its exon 1 and most of exon 2 were replaced by a coding sequence for Venus and neo gene (Fig. 1). WebThis Anti-TIM4/TIMD-4 Antibody, clone Kat5-18 is validated for use in Flow Cytometry and Neutralizing for the detection of ... TIMD-4, Smuckler) is encoded by the Timd4 (also known as B430010N18Rik, Tim4) gene (Gene ID 276891) in murine species. Phagocytes, including macrophages, target apoptotic cells for engulfment by recognizing their ...

Tim4 recognizes carbon nanotubes and mediates ... - Cell Reports

Web15 nov 2007 · Tim4 was expressed in Mac1+ cells in various mouse tissues, including spleen, lymph nodes and fetal liver. Tim4 bound apoptotic cells by recognizing phosphatidylserine via its immunoglobulin domain. The expression of Tim4 in fibroblasts enhanced their ability to engulf apoptotic cells. Web28 mar 2024 · Summary. Official Symbol. TIMD4 provided by HGNC. Official Full Name. T cell immunoglobulin and mucin domain containing 4 provided by HGNC. Primary … system multimedialny mbux

Identification of Tim4 as a phosphatidylserine receptor - PubMed

WebHuman TIM-4 ELISA Kit from Invitrogen (96 Tests). Quantitate human TIM-4 (TIMD4) in serum, ... Protein name. TIM-4 (TIMD4) Protein aliases. ... The TIM-4 gene maps to a … WebTim-4 is a transmembrane protein known as T cell immunoglobulin and mucin domain containing protein-4. It is expressed on antigen-presenting cells and not on T cells. Tim-4 binds to Tim-1 to promote T cell proliferation by enhancing cell … WebBelongs to the immunoglobulin superfamily. TIM family. Tim4/TIMD4 protein name Recommended name T-cell immunoglobulin and mucin domain-containing protein 4 … system mtn snowboard reviews

TIM4 expression by dendritic cells mediates uptake of …

Anti-TIM-4 (TIMD4) Antibodies Invitrogen - Thermo Fisher Scientific

Web14 apr 2024 · TIM4 (T-cell immunoglobulin mucin-4), that recognizes phosphatidylserine (PtdSer) on apoptotic cells (AC), is predominantly expressed on resident peritoneal … Web9 feb 2024 · The sequences of Tim1 and Tim4 guide RNAs (gRNAs) were designed on the software program CRISPRdirect (Naito et al., 2015) as follows: 5′-TGGTCTGTATTGTTGTCGAGTGG-3′, located at exon 2 of Tim1 gene and 5′-GGTGTACTGCTGCCGTATAGAGG-3′, located at exon 2 of Tim4 gene. system music stop androidWebT cell immunoglobulin and mucin domains containing protein 4 (TIM4, TIMD4) is a phosphatidylserine receptor that mediates phagocytosis of apoptotic cells. It is involved in the regulation of T helper cells (Th1 and Th2) immune responses. TIM4 binds apoptotic cells by recognizing phosphatidylserine through its immunoglobulin domain. system muted league

"WebThe Tissue section contains information regarding the expression profile of human gene both on the mRNA and protein level. The protein expression data from 44 normal tissue … " - Tim4 gene name

Tim4 gene name

Tim4 recognizes carbon nanotubes and mediates ... - Cell Reports

Web17 mar 2024 · Targeted cytoplasmic components are sequestered by double-membrane vesicles named ... IL-23 activity in inflammation is associated with a unique gene ... We noticed that the resident TIM4 ... Web12 lug 2024 · Cavity-resident macrophages express high levels of Tim-4, a receptor for phosphatidylserine (PS), and this is associated with reduced numbers of CD8+T cells with tumor-reactive features in pleural effusions and peritoneal ascites from patients with cancer.

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Web26 feb 2024 · TIM-4 gene polymorphisms are associated with asthma in a Chinese Han population. Overexpression of TIM-4 on antigen- presenting cells in transgenic mice … Web1 set 2024 · T-cell immunoglobulin and mucin domain ( TIM) gene family includes three members coding for TIM-1, TIM3, and TIM-4 proteins. The genes of this family are located on chromosome 5q33.2 ( Liu et al., 2024 ).

Web21 feb 2006 · Status. UniProtKB unreviewed (TrEMBL) Organism. Homo sapiens (Human) Amino acids. 262. Protein existence. Evidence at transcript level. Annotation score. Web15 nov 2007 · The antigen recognized by the antibody was identified by expression cloning as a type I transmembrane protein called Tim4 (T-cell immunoglobulin- and mucin …

WebT-cell immunoglobulin and mucin domain-containing protein 4 (UniProt Q6U7R4; also known as SMUCKLER, Spleen, mucin-containing, knockout of lymphotoxin protein, T-cell immunoglobulin mucin receptor 4, T-cell membrane protein 4, TIM-4, TIMD-4) is encoded by the Timd4 (also known as Tim4) gene (Gene ID 276891) in murine species. WebTIM-4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, and this binding leads to T-cell expansion and cytokine production. …

WebStrain Name: C57BL/6-Timd4 tm2(TIMD4) /Bcgen: Common Name : B-hTIM4 mice: Background: C57BL/6: Catalog number: 110837: Aliases : SMUCKLER, TIM4: NCBI Gene ID: 276891: Model validation. mRNA expression analysis. Strain specific analysis of TIM4 gene expression in wild-type C57BL/6 mice and B-hTIM4 mice by RT-PCR. Mouse TIM4 …

T-cell immunoglobulin and mucin domain containing 4 (TIMD-4) also known as T-cell membrane protein 4 (TIM-4) is a protein in humans that is encoded by the TIMD4 gene. TIM-4 genes are in mouse present on chromosome 11B1.1 and in humans on chromosome 5q33.2. TIM-4 contains IgV domain with integrin-binding site as well as a unique metal-ion-dependent ligand binding site for phosphatidyl… system muted league of legendsWeb22 feb 2016 · TIM4 (T cell immunoglobulin mucin domain molecule-4) plays a critical role in the initiation of skewed T helper (Th) 2 polarization. The factors regulating TIM4 expression are unclear. This study ... system motherboard this pcWebAlias : TIMD4, TIM4, SMUCKLER T-cell immunoglobulin and mucin domain containing 4. T-cell immunoglobulin mucin receptor 4. T-cell membrane protein 4. Back to the top Specifications Human TIM4 isoform 1 (pUNO1-hTIM4a) Genbank : JX049980.1 ORF size : 1137 bp Subclone : BspLU11I - NheI Back to the top pUNO1 Contents 20 µg of … system muted micWebBackground: Dendritic cell (DC)-derived immunoglobulin domain molecule (TIM)4 plays a critical role in the initiation of T helper (Th)2 polarization. Vitamin D (VitD) involves the regulation of a number of immune responses. Objectives: This study tests a hypothesis that VitD regulates TIM4 expression in DCs. Methods: Peripheral blood samples were … system music playerWeb25 set 2024 · Previous studies demonstrated that TIM1 was a susceptibility gene for asthma and allergy, which was preferentially expressed on activated Th2 cells; by contract, TIM4 is mainly expressed on antigen-presenting cells (APCs) ( 8 ). system needs for ultratax softwareWeb24 ott 2007 · The antigen recognized by the antibody was identified by expression cloning as a type I transmembrane protein called Tim4 (T-cell immunoglobulin- and mucin … system muting microphoneWebTIM-4 (TIMD4) Antibodies TIM-4 (TIMD4) Antibodies Antibodies that detect TIM-4 (TIMD4) can be used in several scientific applications, including Immunohistochemistry, Western … system net mail smtpclient credentials