Trimethyllysine dioxygenase
WebPubMed WebEnables trimethyllysine dioxygenase activity. Predicted to be involved in carnitine biosynthetic process and negative regulation of oxidoreductase activity. Located in mitochondrion. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human TMLHE (trimethyllysine hydroxylase, epsilon).
Trimethyllysine dioxygenase
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Web{"numberOfHits":1,"results":[{"id":"GO:0005506","isObsolete":false,"name":"iron ion binding","definition":{"text":"Binding to an iron (Fe) ion."},"synonyms":[{"name ... WebDec 1, 2014 · Trimethyllysine hydroxylase (TMLH) catalyses the first step in carnitine biosynthesis – the conversion of N6,N6,N6-trimethyl- l -lysine to 3-hydroxy-N6,N6,N6-trimethyl- l -lysine. By changing carnitine availability it is possible to optimise cardiac energy metabolism, that is beneficial under certain ischemic conditions.
WebApr 10, 2024 · The first step in carnitine biosynthesis is catalyzed by trimethyllysine hydroxylase (TMLH), a non-heme Fe (II) and 2-oxoglutarate (2OG)-dependent oxygenase, … WebJan 14, 2011 · trimethyllysine dioxygenase Synonyms ε -trimethyllysine 2-oxoglutarate dioxygenase oxygenase, trimethyllysine di- TML dioxygenase TML hydroxylase TML- α -ketoglutarate dioxygenase TMLD trimethyllysine α -ketoglutarate dioxygenase CAS registry number 84012-77-1 Keywords Molecular Weight Analytical Chemistry Reaction Type …
WebConverts trimethyllysine (TML) into hydroxytrimethyllysine (HTML) (PubMed:11431483, PubMed:23092983). This gene encodes the protein trimethyllysine dioxygenase which is the first enzyme in the carnitine biosynthesis pathway. Carnitine play an essential role in the transport of activated fatty acids across the inner mitochondrial membrane. The encoded … Webaction of trimethyllysine dioxygenase (TMLD), 3-hydroxy-N-trimethyllysine aldolase and 4-N-trimethylaminobutyralde-hyde dehydrogenase. BB is hydroxylated by g-butyrobetaine dioxygenase (BBD) to form carnitine(6). Carnitine produced in liver and kidney is secreted into the blood and taken up into tissues by novel organic cation transporters (OCTN),
WebWhen trimethyllysine is released from cognate proteins via proteolysis, it serves as a precursor for carnitine biosynthesis. Mitochondrial 6-N-trimethyllysine dioxygenase converts 6-N-trimethyllysine to 3-hydroxy-6-N-trimethyllysine as the …
WebNε,Nε,Nε-Trimethyllysine hydrochloride Empirical Formula (Hill Notation): C9H20N2O2 · HCl CAS No.: 55528-53-5 Molecular Weight: 224.73 Match Criteria: Product Name, Keyword All Photos ( 1) Anti-TMLHE antibody … asd 535-2 manualWeb105727255 - Gene ResultTMLHE trimethyllysine hydroxylase, epsilon [ (Ma's night monkey)] TMLHE trimethyllysine hydroxylase, epsilon [ (Ma's night monkey)] Gene ID: 105727255, … asd1 lunch menuWebProtein target information for Trimethyllysine dioxygenase, mitochondrial (human). Find diseases associated with this biological target and compounds tested against it in … asc utahWebThe trimethyllysine dioxygenase enzyme catalyzes the first step in the carnitine biosynthesis pathway, which is part of amine biosynthesis. Carnitine is a molecule that play an essential role in the transport of activated fatty acids across the inner mitochondrial membrane where they are metabolized. The encoded protein converts trimethyllysine ... asd 535-1 manualWebDec 1, 2007 · The first enzyme of carnitine biosynthesis is the mitochondrial 6-N-trimethyllysine dioxygenase, which converts 6-N-trimethyllysine to 3-hydroxy-6-N-trimethyllysine. Using progressive... asd 535 manualWebMar 14, 2012 · Results: mRNA abundances of PPARA and some of its classical target genes and genes involved in carnitine biosynthesis [trimethyllysine dioxygenase (TMLHE), 4-N-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1), γ-butyrobetaine dioxygenase (BBOX1)] and uptake of carnitine [novel organic cation transporter 2 (SLC22A5)] as well … asd4 lunch menuWebJan 1, 2005 · DmsC, which is known as the membrane anchor subunit, is a 30.8 kDa protein that sits within the cytoplasmic membrane.DmsC has eight transmembrane helices, and … asd-a0721-ab manual